反应详情

To a solution of 2.8 g of 1-(m-nitrophenyl)quinazoline-2,4(1H, 3H)-dione and 30 ml of dimethylformamide was added 0.6 g of approximately 55 % sodium hydride and the solution was stirred for 30 minutes at room temperature. To this was further added 3.6 g of allyl bromide, and the mixture was reacted for 2 hours at room temperature. Then, the solvent was distilled off from the resulting mixture under reduced pressure to leave a residue, to which was added water to precipitate a crude product. This product was recrystallized from methanol to yield 2.9 g of 1(m-nitrophenyl)-3 -allylquinazoline- 2,4(1H, 3H)-dione as light brown needles, melting at 165°-166° C.

1. customthe mixture was reacted for 2 hours at room temperature
2. distillationThen, the solvent was distilled off from the resulting mixture under reduced pressure
3. customto leave a residue
4. customto precipitate a crude product
5. customThis product was recrystallized from methanol