反应详情

3.0 g of 2-(m-nitroanilino)-N-allylbenzamide was dissolved in 20 ml of tetrahydrofuran. To the solution was added 1.0 g of approximately 50 % sodium hydride and stirring was performed for 30 minutes. To this was added dropwise under cooling 4.6 g of m-chlorophenyl isocyanate, and the mixture was stirred for one hour, and then refluxed for 5 hours. After the reaction was complete, the solvent was distilled off from the resulting mixture. The residue thus obtained was recrystallized from methanol to give 2.3 g of 1-(m-nitrophenyl)-3-allylquinazoline-2,4(1H, 3H)-dione as colorless needles, melting at 165°-166° C.

1. additionTo this was added dropwise
2. stirringthe mixture was stirred for one hour
3. temperaturerefluxed for 5 hours
4. distillationthe solvent was distilled off from the resulting mixture
5. customThe residue thus obtained
6. customwas recrystallized from methanol