Hydrochloric Acid → HCID 21444156, compound

HRID 328163Notes

Reaction equation

HRID 328163 reaction equation
[OH-].[Na+].O.[N+:4]([C:7]1[CH:8]=[C:9]([CH2:17][C:18]([O:20]C)=[O:19])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]#[CH:16])([O-:6])=[O:5].Cl>CO>[N+:4]([C:7]1[CH:8]=[C:9]([CH2:17][C:18]([OH:20])=[O:19])[CH:10]=[CH:11][C:12]=1[O:13][CH2:14][C:15]#[CH:16])([O-:6])=[O:5]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 21444154HCID 21444154, compound

Product 1

HCID 21444156HCID 21444156, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a mixed solution of 0.5g of sodium hydroxide, 5 ml of water and 2ml of metanol 0.7g of methyl 3-nitro-4-propargyloxyphenylacetate was added and heated on a water bath for 30 minutes. After cooling, the solution was neutralized with 10% hydrochloric acid and the thus obtained crystals were recrystallized from ether-n-hexane to give the object compound having m.p. 135° - 137° C in a yield of 0.6g (90.6%).

Workup

  1. temperatureheated on a water bath for 30 minutes
  2. temperatureAfter cooling
  3. customthe thus obtained crystals were recrystallized from ether-n-hexane
  4. customto give the object compound

Sources & evidence

ORD record
ord-3410ea1ec9074bf5b3ef87e5ec5350da
Source dataset
uspto-grants-1977_04
Patent number
US04016193

Reaction notes

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