反应详情

A solution of 0.7 g. of NaNO2 in 3 ml. of water is added dropwise to a stirred solution of 3.5 g. of 2-(4-phenyl-4-hydroxypiperidinomethyl)-6-amino-1-tetralone in 10 ml. of 4 N hydrochloric acid. The mixture is warmed until nitrogen evolution has ceased. It is cooled, neutralized with potassium carbonate and worked up with chloroform in the customary manner. 2-(4-Phenyl-4-hydroxypiperdinomethyl)-6-hydroxy-1-tetralone is obtained. EXAMPLE 5

1. temperatureThe mixture is warmed until nitrogen evolution
2. temperatureIt is cooled