Water → HCID 178443253, compound

HRID 328347Notes

Reaction equation

HRID 328347 reaction equation
[K].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]([N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[C:22]1[N:23]=[CH:24][S:25][CH:26]=1)=[O:12])([OH:4])=[O:3].O.Cl.[CH2:29]([NH:41][C:42]([NH2:44])=[NH:43])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>C(O)(C)C>[CH2:29]([NH:41][C:42]([NH2:44])=[NH2+:43])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40].[C:2]([CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][O:10][C:11]([N:13]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N:15]=[C:14]1[C:22]1[N:23]=[CH:24][S:25][CH:26]=1)=[O:12])([OH:4])=[O:3]

Participants

5

Reactant 3

HCID 962Water2×HCID 68118986HCID 68118986, compoundHCID 178443245HCID 178443245, compound

Product 1

HCID 178443253HCID 178443253, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A solution of 1.22 g. (3.0 mmoles) of 1-(5-carboxypentyloxycarbonyl)-2-(4-thiazolyl)-benzimidazole potassium salt in 10 ml. of water is added gradually to a stirred solution of 3.3 mmoles of n-dodecylguanidine hydrochloride in 20 ml. of water containing isopropanol. The product precipitates immediately and is stirred for 45 minutes, filtered and washed with water, methanol and acetone affording 1.19 g. of 1-(5-carboxypentyloxycarbonyl)-2-(4-thiazolyl)-benzimidazole n-dodecylguanidinium salt,

Workup

  1. customThe product precipitates immediately
  2. filtrationfiltered
  3. washwashed with water, methanol and acetone affording 1.19 g

Sources & evidence

ORD record
ord-6dc3b57eb65745afa19afe7685bd70bc
Source dataset
uspto-grants-1977_04
Patent number
US04017504

Reaction notes

Loading…