Water → HCID 152774376, compound
Reaction equation
[CH3:1][N:2]([CH3:9])[C:3]([NH:5][C:6]([NH2:8])=[S:7])=[O:4].O.[OH-].[Na+].I[CH2:14][CH3:15]>CO>[CH3:1][N:2]([CH3:9])[C:3](=[O:4])[NH:5][C:6](=[NH:8])[S:7][CH2:14][CH3:15]Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 25 °C
Procedure
To a solution of 58.5 parts of 1,1-dimethyl-4-thiobiuret in 200 parts of water, 200 parts of methanol and 32 parts of 50% aqueous sodium hydroxide are added at 25° C. within 10 minutes 62.5 parts of iodoethane. The reaction mass is then stirred at 25° C. for 2 hours. Evaporation of the methanol and part of the water under vacuum gives 64 parts of crude ethyl 4,4-dimethylthioallophanimidate (a compound of formula II), which is recrystallized from water-methanol (50:50) and shows a melting point of 90°-93° C.
Workup
- customEvaporation of the methanol and part of the water under vacuum
Sources & evidence
- ORD record
- ord-866e3257a4f4471da408a252cc827040
- Source dataset
- uspto-grants-1977_04
- Patent number
- US04017529
Reaction notes
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