Water → HCID 21442792, compound

HRID 328582Notes

Reaction equation

HRID 328582 reaction equation
[H-].[Al+3].[Li+].[H-].[H-].[H-].[C:7]([N:10]1[CH2:15][CH2:14][O:13][CH:12]([CH2:16][N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][CH2:20][C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]2=3)[CH2:11]1)(=O)[CH3:8].O>O1CCCC1>[CH2:7]([N:10]1[CH2:15][CH2:14][O:13][CH:12]([CH2:16][N:17]2[C:23]3[CH:24]=[CH:25][CH:26]=[CH:27][C:22]=3[CH2:21][CH2:20][C:19]3[CH:28]=[CH:29][CH:30]=[CH:31][C:18]2=3)[CH2:11]1)[CH3:8]

Participants

5

Reactant 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 21442817HCID 21442817, compound

Product 1

HCID 21442792HCID 21442792, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a suspension of lithium aluminium hydride (0.08 g) in tetrahydrofuran was added a solution of 5-(4-acetyl-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine (0.34 g) in tetrahydrofuran under ice-cooling, and the resulting mixture was stirred under reflux for 1 hour. the reaction mixture was cooled, admixed with water and extracted with benzene. The benzene extract was washed with water, dried over anhydrous sodium sulfate and evaporated to afford 5-(4-ethyl-2-morpholinylmethyl)-10,11-dihydro-5H-dibenz[b,f]azepine as an oily substance. M.P. 210°-211° C (oxalate).

Workup

  1. temperaturecooling
  2. temperatureunder reflux for 1 hour
  3. temperaturethe reaction mixture was cooled
  4. extractionextracted with benzene
  5. extractionThe benzene extract
  6. washwas washed with water
  7. dry with materialdried over anhydrous sodium sulfate
  8. customevaporated

Sources & evidence

ORD record
ord-3c63fc673d914dfca967f540bbec5cc3
Source dataset
uspto-grants-1977_04
Patent number
US04017621

Reaction notes

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