Hydrochloric Acid → 2-Amino-3,3-diphenylpropanoic acid hydrochloride

HRID 32864Notes

Reaction equation

HRID 32864 reaction equation
C([NH:4][CH:5]([CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6]([OH:8])=[O:7])(=O)C.[ClH:22]>>[ClH:22].[NH2:4][CH:5]([CH:9]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 11022400Phenylalanine,N-acetyl--phenyl-

Product 1

HCID 197724602-Amino-3,3-diphenylpropanoic acid hydrochloride

Procedure

A solution (21 mL) of 2-acetylamino-3,3-diphenylpropanoic acid (2.83 g, 10 mmol) in concentrated hydrochloric acid was stirred at 90° C. for 5 hrs, and the reaction mixture was cooled in an ice bath to allow solid precipitation. The solid was collected by filtration and dried to give the title compound (2.65 g).

Workup

  1. temperaturethe reaction mixture was cooled in an ice bath
  2. customsolid precipitation
  3. filtrationThe solid was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-180659972f66413a9d3b5f339b90f27f
Source dataset
uspto-grants-2008_09
Patent number
US07427688B2

Reaction notes

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