Hydrochloric Acid → 2-Amino-3,3-bis(4-fluorophenyl)propanoic acid hydrochloride

HRID 32869Notes

Reaction equation

HRID 32869 reaction equation
C([NH:4][CH:5]([CH:9]([C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1)[C:10]1[CH:15]=[CH:14][C:13]([F:16])=[CH:12][CH:11]=1)[C:6]([OH:8])=[O:7])(=O)C.[ClH:24]>>[ClH:24].[NH2:4][CH:5]([CH:9]([C:10]1[CH:11]=[CH:12][C:13]([F:16])=[CH:14][CH:15]=1)[C:17]1[CH:18]=[CH:19][C:20]([F:23])=[CH:21][CH:22]=1)[C:6]([OH:8])=[O:7]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 119778292-Acetylamino-3,3-bis(4-fluorophenyl)propanoic acid

Product 1

HCID 159809952-Amino-3,3-bis(4-fluorophenyl)propanoic acid hydrochloride

Procedure

A solution (144 mL) of 2-acetylamino-3,3-bis(4-fluorophenyl)propanoic acid (25.34 g, 79.9 mmol) in concentrated hydrochloric acid was stirred at 90° C. for 5 hrs, and cooled in an ice bath to allow solid precipitation. The solid was collected by filtration and dried to give the title compound (22.79 g).

Workup

  1. temperaturecooled in an ice bath
  2. customsolid precipitation
  3. filtrationThe solid was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-9fa9efe74a6043d69ddcb7b315c8ad65
Source dataset
uspto-grants-2008_09
Patent number
US07427688B2

Reaction notes

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