Methyl iodide → HCID 21440002, compound

HRID 328733Notes

Reaction equation

HRID 328733 reaction equation
[NH:1]([C:8]1[S:9][CH:10]=[C:11]([CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[N:12]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CI.[C:22](=O)([O-])[O-].[K+].[K+]>C(O)C>[C:2]1([N:1]=[C:8]2[N:12]([CH3:22])[C:11]([CH:13]([CH3:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:10][S:9]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 21439976HCID 21439976, compound

Product 1

HCID 21440002HCID 21440002, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 2-(2-anilinothiazol-4-yl)-propionate (6.15 g), methyl iodide (17 ml) and ethanol (17 ml) is heated at 100° C for 11.5 hours in a sealed tube. The resultant mixture is treated with potassium carbonate in the same manner as in Example 1 (2) to give ethyl 2-(2-phenylimino-3-methyl-4-thiazolin-4-yl)propionate (1.6 g) melting at 80°-81° C (recrystallized from ether/hexane).

Sources & evidence

ORD record
ord-70cffe2e7946483c804b667d004b1e70
Source dataset
uspto-grants-1977_04
Patent number
US04018785

Reaction notes

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