Hydrochloric Acid → HCID 178463047, compound

HRID 329180Notes

Reaction equation

HRID 329180 reaction equation
[ClH:1].[CH3:2][C:3]1[C:11]2[C:6](=[N:7][C:8]([OH:20])=[C:9]([CH2:13][N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:10]=2[CH3:12])[N:5]([CH2:21][CH3:22])[N:4]=1>CN(C)C=O>[ClH:1].[CH3:2][C:3]1[C:11]2[C:6](=[N:7][C:8]([OH:20])=[C:9]([CH2:13][N:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[C:10]=2[CH3:12])[N:5]([CH2:21][CH3:22])[N:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 178463046HCID 178463046, compound

Product 1

HCID 178463047HCID 178463047, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The hydrochloric acid salt is obtained by dissolving 18 g. of 3,4-dimethyl-1-ethyl-5-(1-piperidinylmethyl)-1H-pyrazolo[3,4-b]pyridin-6-ol in 250 ml. of hot dimethylformamide and adding 10 ml. of alcoholic hydrochloric acid (332 g. HCl/1). After cooling 17.8 g. (88%) of the hydrochloride (1:1) are obtained, m.p. 291°-294° (dec.). The hydrobromide is obtained by utilizing hydrobromic acid instead of hydrochloric acid.

Workup

  1. dissolutionby dissolving 18 g
  2. temperatureAfter cooling 17.8 g

Sources & evidence

ORD record
ord-13683a3a196b4b40974a1bef57b71aa5
Source dataset
uspto-grants-1977_04
Patent number
US04020072

Reaction notes

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