反应详情

To a 125 ml round-bottomed flask equipped with condenser and N2 inlet were added 2.39 g (7.5 mmol) of 4-(4-(2-chloroethyl)phenyl)-2-methylthiazole hydrobromide, 1.59 g (7.5 mmol) of N-(1-naphthyl)piperazine, 1.31 ml (7.5 mmol) of diisopropylethylamine, 1.59 g (15 mmol) of sodium carbonate, 5 mg of sodium iodide, and 50 ml of methylisobutylketone. The reaction was heated at reflux for 5 days, cooled, and the precipitate filtered. The solid was taken up in methylene chloride, washed with sodium bicarbonate, dried over sodium sulfate, treated with methylene chloride saturated with hydrochloride, evaporated, and the residue triturated with ether to afford a white solid, m.p. 305°-307° C., 1.76 g (48%).

1. customTo a 125 ml round-bottomed flask equipped with condenser and N2 inlet
2. temperatureThe reaction was heated
3. temperatureat reflux for 5 days
4. temperaturecooled
5. filtrationthe precipitate filtered
6. washwashed with sodium bicarbonate
7. dry with materialdried over sodium sulfate
8. additiontreated with methylene chloride saturated with hydrochloride
9. customevaporated
10. customthe residue triturated with ether
11. customto afford a white solid, m.p. 305°-307° C., 1.76 g (48%)