反应详情

To a solution of 2.46 g p-[5-(1-imidazolyl)pentyloxy]phenol and 1.2 ml ethyl bromoacetate in 25 ml anhydrous N,N-dimethylformamide, was added under ice cooling and with stirring 440 mg of 60% sodium hydride in oil, and stirring was continued at room temperature for ten minutes. The solvent was distilled off, the residue was dissolved in chloroform, and the solution was washed with water and dried over anhydrous sodium sulfate. After distilling off the chloroform, the residue was purified by silical gel column chromatography, affording 2.7 g of ethyl p-[5-(1-imidazol-yl)pentyloxy]phenoxyacetate as oil.

1. waitwas continued at room temperature for ten minutes
2. distillationThe solvent was distilled off
3. dissolutionthe residue was dissolved in chloroform
4. washthe solution was washed with water
5. dry with materialdried over anhydrous sodium sulfate
6. distillationAfter distilling off the chloroform
7. customthe residue was purified by silical gel column chromatography