反应详情

To a solution of 2.16 g ethyl 6-[p-(5-bromopentyloxy]phenoxy)-2,2-dimethylhexanoate in 10 ml DMF, was added with stirring 0.55 g sodium salt of 1,2,4-triazole at room temperature, and stirring was continued overnight. DMF was distilled off under reduced pressure, the residue was extracted with chloroform, and the extract was washed with water, dried and concentrated. The crude product thus obtained was purified by silica gel column chromatography, affording 1.21 g of ethyl 6-[p-[5-(1,2,4-triazol-1-yl)pentyloxy]phenoxy]-2,2-dimethylhexanoate.

1. distillationDMF was distilled off under reduced pressure
2. extractionthe residue was extracted with chloroform
3. washthe extract was washed with water
4. customdried
5. concentrationconcentrated
6. customThe crude product thus obtained
7. customwas purified by silica gel column chromatography