Dimethyl Sulfoxide → HCID 14456778, compound

HRID 329540Notes

Reaction equation

C(Cl)(=O)C(Cl)=O.CS(C)=O.[OH:11][CH:12]([CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14].C(N(CC)CC)C>ClCCl>[O:11]=[C:12]([CH2:20][CH2:21][C:22]([O:24][CH3:25])=[O:23])[C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14]

Participants

Conditions

Temperature: -70 °C

Procedure

To a solution of 0.39 ml of oxalyl chloride in 12 ml of dichloromethane was added under nitrogen atmosphere at -70° C. while stirring a solution of 0.60 ml of dimethyl sulfoxide in 4 ml of dichloromethane. To the mixture was added a solution of 0.95 g of 1-t-butyl 5-methyl 2-hydoxyglutarate obtained as above in 3.5 ml of dichloromethane. The whole mixture was stirred for 15 minutes at -70° C., to which was added 3.0 ml of triethylamine. The temperature of the reaction mixture was raised to -40° C., and the reaction mixture was poured into ice-water, followed by extraction with dichloromethane. The extract was wahsed with water, dilute acetic acid and water, in sequence, which was then dried (Na2SO4), followed by distilling off the solvent. The residue was subjected to a silica gel column chromatography, eluting with hexane-ethyl acetate (5:1), followed by combining fractions containing the end product. Thus combined eluate was concentrated under reduced pressure to give 0.60 g of 1-t-butyl 5-methyl 2-oxoglutarate as a colorless oily substance.

Workup

temperatureThe temperature of the reaction mixture was raised to -40° C.
extractionfollowed by extraction with dichloromethane
dry with materialwas then dried (Na2SO4)
distillationby distilling off the solvent
washeluting with hexane-ethyl acetate (5:1)
additioncontaining the end product
concentrationThus combined eluate was concentrated under reduced pressure

Sources & evidence

ORD record: ord-4a8d544b810b42eb929148538e376782
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04891427

Reaction notes

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