Ethyl 5-methylisoxazole-4-carboxylate → 5-Methylisoxazole-4-carboxylic acid

HRID 329779Notes

Reaction equation

HRID 329779 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[CH:4][C:3]=1[C:7]([O:9]CC)=[O:8]>Cl>[CH3:1][C:2]1[O:6][N:5]=[CH:4][C:3]=1[C:7]([OH:9])=[O:8]

Participants

3

Reactant 1

HCID 7009317Ethyl 5-methylisoxazole-4-carboxylate

Product 1

HCID 14252405-Methylisoxazole-4-carboxylic acidYield 78.9%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Ethyl 5-methylisoxazol-4-yl carboxylate (65 g) was heated under reflux in 10M HCl (500 ml) for 3 hours. On cooling the product crystallised out. This was filtered and dried giving 42 g of a white crystalline solid, m.p. 134°-136° C.

Workup

  1. temperatureOn cooling the product
  2. customcrystallised out
  3. filtrationThis was filtered
  4. customdried

Sources & evidence

ORD record
ord-a9c8b6f7578545e8abd28af815a73ad5
Source dataset
uspto-grants-1990_01
Patent number
US04892963

Reaction notes

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