反应详情

A slurry of 179 Kg of 1-(aminomethyl)-cyclohexaneacetic acid monohydrate and 1266 Kg of anhydrous methanol is heated to 60° C. to give a complete solution. The solution is diluted with 1266 Kg of anhydrous 2-propanol and the solution is cooled to 20° C. to 25° C. for two hours and then is cooled to -8° C. to -10° C. for twenty hours. The resulting slurry is centrifuged and the precipitate is dried in vacuo at 35° C. for forty-eight hours to yield 145 Kg of white, crystalline 1-(aminomethyl)-cyclohexaneacetic acid.

1. customto give a complete solution
2. temperaturethe solution is cooled to 20° C. to 25° C. for two hours
3. temperatureis cooled to -8° C. to -10° C. for twenty hours
4. customthe precipitate is dried in vacuo at 35° C. for forty-eight hours