Hydrochloric Acid → HCID 13013076, compound

HRID 330286Notes

Reaction equation

HRID 330286 reaction equation
Cl[C:2]([CH2:4][C:5]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:6]=1[OH:12])=[CH2:3].Cl>CCOCC>[F:11][C:9]1[CH:8]=[CH:7][C:6]2[O:12][C:2]([CH3:3])=[CH:4][C:5]=2[CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 14819357HCID 14819357, compound

Product 1

HCID 13013076HCID 13013076, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

According to the procedure of W. K. Anderson, et al., J. Chem. Soc., Perkin, 1, 1 (1976), a mixture of 2-(2-chloro-1-propen-3-yl)-4-fluorophenol (20.9 g, 0.112 mol) and concentrated hydrochloric acid (114 mL) was heated at 85°-89° C. for 24 hours. The mixture was cooled and diluted with ether. The ethereal layer was separated and washed with H2O, 5% KOH, and H2O, dried (MgSO4), and concentrated to give 12.40 g (74%) of product as a brown oil.

Workup

  1. temperaturewas heated at 85°-89° C. for 24 hours
  2. temperatureThe mixture was cooled
  3. customThe ethereal layer was separated
  4. washwashed with H2O, 5% KOH, and H2O
  5. dry with materialdried (MgSO4)
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-c10f8806db234132a417cad997d2da72
Source dataset
uspto-grants-1990_01
Patent number
US04895860

Reaction notes

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