反应详情

温度

95 °C

A mixture of indan (50.0 g, 0.423 mol), paraformaldehyde (23.3 g), concentrated HCl (74 mL), 85% H3PO4 (33 mL), and acetic acid (54 mL) was heated at 95° C. for 6 hours. The mixture was cooled and diluted with ether (200 mL). The organic phase was separated and washed with H2O (2×200 mL), saturated aqueous NaHCO3 (200 mL), H2O (200 mL), dried (MgSO4), and concentrated. The crude product was distilled under high vacuum (0.8 mm) to give 35.2 g (50%) as a colorless oil, b.p. 89° C.

1. temperatureThe mixture was cooled
2. customThe organic phase was separated
3. washwashed with H2O (2×200 mL), saturated aqueous NaHCO3 (200 mL), H2O (200 mL)
4. dry with materialdried (MgSO4)
5. concentrationconcentrated
6. distillationThe crude product was distilled under high vacuum (0.8 mm)
7. customto give 35.2 g (50%) as a colorless oil, b.p. 89° C.