Hydrochloric Acid → HCID 131716259, compound

HRID 330311Notes

Reaction equation

HRID 330311 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH:6]=[CH:5][C:4]=1[OH:24].[Cl:25][C:26]1[N:31]=[C:30]([NH:32][CH:33]([CH2:48][CH3:49])[C:34]2[CH:39]=[CH:38][C:37]([O:40][C:41]3[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=3)=[CH:36][CH:35]=2)[CH:29]=[C:28]([CH2:50][CH3:51])[N:27]=1.Cl>CCOCC>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][NH:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][CH2:20][CH2:21][CH2:22][NH2:23])[CH:6]=[CH:5][C:4]=1[OH:24].[ClH:25].[Cl:25][C:26]1[N:31]=[C:30]([NH:32][CH:33]([CH2:48][CH3:49])[C:34]2[CH:35]=[CH:36][C:37]([O:40][C:41]3[CH:46]=[CH:45][C:44]([F:47])=[CH:43][CH:42]=3)=[CH:38][CH:39]=2)[CH:29]=[C:28]([CH2:50][CH3:51])[N:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131716261HCID 131716261, compound

Product 1

HCID 131716259HCID 131716259, compoundYield 190.4%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

In 20 ml of anhydrous ether was dissolved 1.0 g of dl-5-chloro-6-ethyl-4-[α-ethyl-4-(4-fluorophenoxy)benzyl]aminopyrimidine obtained in Example 2 and the dried hydrochloric acid gas was blown into the mixture. Ether was removed from the separated oily product, and the product obtained was washed with n-hexane to give 1.0 g of the desired product as a colorless viscous product.

Workup

  1. customEther was removed from the separated oily product
  2. customthe product obtained
  3. washwas washed with n-hexane

Sources & evidence

ORD record
ord-432faa0eac7742beacfa68867027b355
Source dataset
uspto-grants-1990_01
Patent number
US04895849

Reaction notes

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