Water → HCID 14626766, compound

HRID 330466Notes

Reaction equation

HRID 330466 reaction equation
[Cl:1]N1C(=O)CCC1=O.[CH:9]1[C:14]2[C:15]3[N:16]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][C:26]=4[CH:27]=3)[CH2:17][C:18](=[O:20])[NH:19][C:13]=2[CH:12]=[CH:11][CH:10]=1.O>CN(C)C=O>[Cl:1][C:27]1[C:26]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[N:16]2[C:15]=1[C:14]1[CH:9]=[CH:10][CH:11]=[CH:12][C:13]=1[NH:19][C:18](=[O:20])[CH2:17]2

Participants

5

Reactant 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 14626765HCID 14626765, compound

Product 1

HCID 14626766HCID 14626766, compoundYield 90.7%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

A solution of 1.77 g N-chlorosuccinimide in 50 ml DMF (dimethylformamide) was added dropwise to a mixture of 3.0 g indolo[1,2-d][1,4]benzodiazepin-6(7H)-one in 50 ml dimethylformamide at room temperature. The resulting solution was stirred overnight at room temperature and then poured into 800 ml water. The precipitate was collected, washed with water and dried (P2O5) under vacuum to give 3.1 g solid;

Workup

  1. customThe precipitate was collected
  2. washwashed with water
  3. dry with materialdried (P2O5) under vacuum

Sources & evidence

ORD record
ord-214f9f742edb47bdba368f08ebddc419
Source dataset
uspto-grants-1990_01
Patent number
US04897392

Reaction notes

Loading…