Sodium Bicarbonate → HCID 178441000, compound

HRID 330622Notes

Reaction equation

[P:1]([O-:33])([O-:32])([O:3][C:4]1[CH:9]=[CH:8][C:7](/[C:10](/[C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][CH2:28][N:29]([CH3:31])[CH3:30])=[CH:22][CH:21]=2)=[C:11](/[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)\[CH2:12][CH3:13])=[CH:6][CH:5]=1)=[O:2].C(=O)([O-])O.[Na+:38]>>[P:1]([OH:33])([OH:32])([OH:3])=[O:2].[CH3:31][N:29]([CH3:30])[CH2:28][CH2:27][O:26][C:23]1[CH:22]=[CH:21][C:20](/[C:10](/[C:7]2[CH:6]=[CH:5][C:4]([Na:38])=[CH:9][CH:8]=2)=[C:11](\[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)/[CH2:12][CH3:13])=[CH:25][CH:24]=1

Participants

Reactant 2

HCID 516892Sodium Bicarbonate

HCID 19869197HCID 19869197, compound

Product 1

HCID 178441000HCID 178441000, compoundYield 76.2%

Procedure

In a 2% aqueous solution of sodium hydrogen carbonate (20 ml) was dissolved Compound 1 (1.0 g) and the solution was applied to a column of MCI gel HP-20P (product of Mitsubishi Chemical Ind., Japan, high porous polymer). The column was washed with distilled water until the effluent became neutral and, then, elution was carried out with acetone-water (20:80). The eluate (500 ml) was concentrated to about 1/3 of its initial volume and lyophilized to give 0.8 g (yield 76.2%) of the title compound as a colorless powder.

Workup

washThe column was washed with distilled water until the effluent
washelution
concentrationThe eluate (500 ml) was concentrated to about 1/3 of its initial volume

Sources & evidence

ORD record: ord-f8a14efa176241afa978d9b4056e5c91
Source dataset: uspto-grants-1990_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04897503

Reaction notes

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