Hydrochloric Acid → HCID 131731994, compound

HRID 331046Notes

Reaction equation

HRID 331046 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH:12]3[CH2:13][CH2:14][CH:9]2[CH2:10][CH2:11]3)=[CH:4][C:3]=1[O:15]COC.[ClH:19].O1CCOCC1>C1COCC1.CO>[ClH:19].[CH:12]12[N:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[C:3]([OH:15])[CH:4]=3)[CH:9]([CH2:14][CH2:13]1)[CH2:10][CH2:11]2

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 89264128HCID 89264128, compound

Product 1

HCID 131731994HCID 131731994, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 7-(4-fluoro-3-(methoxymethoxy)phenyl)-7-azabicyclo[2.2.1]heptane (D81) (423 mg, 1.683 mmol) in THF (10 mL) and MeOH (1 mL) was added 4M solution of HCl in 1,4-dioxane (2.104 mL, 8.42 mmol). The mixture was stirred overnight at RT. The reaction mixture was evaporated in vacuo to give the title compound (427 mg), which was carried over to next step without purification. LCMS (A): m/z [(M−HCl)+H]+ 208, Cl2H14FNO.HCl requires 243 (acidic).

Workup

  1. customThe reaction mixture was evaporated in vacuo

Sources & evidence

ORD record
ord-25ecab25089f41d79bf5560e547d15d3
Source dataset
uspto-grants-2014_11
Patent number
US08877742B2

Reaction notes

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