Potassium Carbonate → 2-bromo-6-hydroxy-1H-indenone

HRID 331253Notes

Reaction equation

HRID 331253 reaction equation
[Br:1][C:2]1[C:3](=[O:11])[C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.C([O-])([O-])=[O:13].[K+].[K+]>CO>[Br:1][C:2]1[C:3](=[O:11])[C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[C:6]([OH:13])[CH:5]=2

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 99906492-Bromoindenone

Product 1

HCID 703171292-bromo-6-hydroxy-1H-indenone

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1 to 1.2 eq of the 2-bromo-1H-indenone prepared in Step 4 is dissolved in MeOH, and then K2CO3 (1 to 2 eq) is added thereto. The resulting mixture is stirred at room temperature for 2 to 7 h, to obtain the 2-bromo-6-hydroxy-1H-indenone of formula 8 in which acetyl group is removed.

Sources & evidence

ORD record
ord-65de89de0233422f994a3a1f0108cdff
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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