Hydrochloric Acid → 6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

HRID 331266Notes

Reaction equation

HRID 331266 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:3][CH2:2]1.[ClH:32].C(OCC)C>C(Cl)Cl>[ClH:32].[O:1]1[CH2:2][CH2:3][N:4]([CH2:7][CH2:8][O:9][C:10]2[CH:18]=[C:17]3[C:13]([C:14]([C:26]4[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=4)=[C:15]([C:20]4[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=4)[C:16]3=[O:19])=[CH:12][CH:11]=2)[CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 509405096-(2-morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one

Product 1

HCID 703126206-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one hydrochloride salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

6-(2-Morpholinoethoxy)-3-phenyl-2-(pyridin-3-yl)-1H-inden-1-one (500 mg, 1.21 mmol) obtained in Step 7 was placed into a flask and dissolved in CH2Cl2 (4.0 mL). To the resulting solution was added 1.0M HCl in diethyl ether (1.21 mL, 1 eq). The solvents were removed by rotary evaporation under reduced pressure to give the desired product in quantitative yield.

Workup

  1. customThe solvents were removed by rotary evaporation under reduced pressure

Sources & evidence

ORD record
ord-36348c8524db40d7ba1d0b22bfb36247
Source dataset
uspto-grants-2014_11
Patent number
US08877747B2

Reaction notes

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