Thionyl Chloride → 2-Chloro-5-(ethylsulfonyl)benzoxazole

HRID 33146Notes

Reaction equation

HRID 33146 reaction equation
[CH2:1]([S:3]([C:6]1[CH:7]=[CH:8][C:9]2[O:13][C:12](S)=[N:11][C:10]=2[CH:15]=1)(=[O:5])=[O:4])[CH3:2].S(Cl)([Cl:18])=O>CN(C)C=O>[Cl:18][C:12]1[O:13][C:9]2[CH:8]=[CH:7][C:6]([S:3]([CH2:1][CH3:2])(=[O:5])=[O:4])=[CH:15][C:10]=2[N:11]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178477630HCID 178477630, compound

Product 1

HCID 589063162-Chloro-5-(ethylsulfonyl)benzoxazole

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideCatalyst

Procedure

8 mmol of 5-Ethanesulfonyl-benzooxazole-2-thiol were dissolved in 10 ml of thionyl chloride. 1 drop of N,N-dimethylformamide is added and the reaction mixture hold at 65° for 45 min. Evaporation of the solvent yields the title compound as brownish solid.

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-c56e0eb749eb40fe866efc426817aff3
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

Loading…