2-Isopropoxy-5-methylsulfonylbenzoic acid → HCID 58906307, compound

HRID 33154Notes

Reaction equation

HRID 33154 reaction equation
[CH:1]([O:4][C:5]1[CH:13]=[CH:12][C:11]([S:14]([CH3:17])(=[O:16])=[O:15])=[CH:10][C:6]=1[C:7]([OH:9])=O)([CH3:3])[CH3:2].Cl.[CH3:19][O:20][C:21]([C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[S:31][C:30]([N:32]3[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]3)=[N:29][C:28]=12)=[O:22]>O1CCCC1>[CH3:19][O:20][C:21]([C:23]1[CH:24]=[CH:25][CH:26]=[C:27]2[S:31][C:30]([N:32]3[CH2:37][CH2:36][N:35]([C:7](=[O:9])[C:6]4[CH:10]=[C:11]([S:14]([CH3:17])(=[O:16])=[O:15])[CH:12]=[CH:13][C:5]=4[O:4][CH:1]([CH3:2])[CH3:3])[CH2:34][CH2:33]3)=[N:29][C:28]=12)=[O:22]

Participants

4

Reactant 2

HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acidHCID 689722872-Piperazin-1-yl-benzothiazole-4-carboxylic acid methyl ester hydrochloride

Product 1

HCID 58906307HCID 58906307, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared in analogy to example 1.1 b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 2-Piperazin-1-yl-benzothiazole-4-carboxylic acid methyl ester hydrochloride in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate), and the residue was then triturated in ether to yield the title compound as a white solid.

Workup

  1. customThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)
  2. customthe residue was then triturated in ether

Sources & evidence

ORD record
ord-4ab9aa2551a14e6084c107e56cd16f4e
Source dataset
uspto-grants-2008_09
Patent number
US07429585B2

Reaction notes

Loading…