Benzaldehyde → HCID 66746789, compound

HRID 331679Notes

Reaction equation

HRID 331679 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([F:12])=[C:7]([CH:11]=1)[CH2:8][C:9]#[N:10].[O-]CC.[Na+].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>C(O)C>[F:12][C:6]1[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:11][C:7]=1[C:8](=[CH:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:9]#[N:10]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 2723922Sodium ethoxideHCID 23074300(2-Fluoro-5-methoxyphenyl)acetonitrile

Product 1

HCID 66746789HCID 66746789, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 5-methoxy-2-fluorobenzylcyanide (8 g, 48.4 mmol) in 200 ml ethanol was added sodium ethoxide 21% in ethanol (19.89 ml, 53.3 mmol) and benzaldehyde (4.92 ml, 48.4 mmol). The reaction mixture was stirred at room temperature over night and concentrated to ½ volume, filtered and washed with small amount of ether, and dried under high vacuum to obtain yellow crystals.

Workup

  1. concentrationconcentrated
  2. filtrationfiltered
  3. washwashed with small amount of ether
  4. customdried under high vacuum
  5. customto obtain yellow crystals

Sources & evidence

ORD record
ord-576d8def76114c7584aa2291549441c4
Source dataset
uspto-grants-2014_11
Patent number
US08877794B2

Reaction notes

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