Benzaldehyde → HCID 66747570, compound

HRID 331701Notes

Reaction equation

HRID 331701 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#[N:10])=[CH:4][C:3]=1[O:11][CH3:12].[O-]CC.[Na+].[CH:17](=O)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>CCO>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[CH:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:9]#[N:10])=[CH:4][C:3]=1[O:11][CH3:12]

Participants

5

Reactant 3

HCID 240BenzaldehydeHCID 2723922Sodium ethoxideHCID 17989296(4-Fluoro-3-methoxyphenyl)acetonitrile

Product 1

HCID 66747570HCID 66747570, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 4-fluoro-3-methoxyphenylacetonitrile (10.8 g, 65.4 mmol) in 200 ml EtOH was added a sodium ethoxide 21% solution in EtOH (26.9 ml, 71.9 mmol). Benzaldehyde was added (6.64 ml, 65.4 mmol) and stirred at room temperature over night. The white precipitate was filtered and washed with diethylether and dried to obtain 14.23 g of pale yellow crystals (86%).

Workup

  1. filtrationThe white precipitate was filtered
  2. washwashed with diethylether
  3. customdried

Sources & evidence

ORD record
ord-7da5e01ce3eb4153b343c9ae25f0e49d
Source dataset
uspto-grants-2014_11
Patent number
US08877794B2

Reaction notes

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