Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide

HRID 33198Notes

Reaction equation

HRID 33198 reaction equation
C[O:2][C:3]1[CH:13]=[CH:12][C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:13]=[CH:12][C:6]2[CH2:7][CH2:8][NH:9][CH2:10][CH2:11][C:5]=2[CH:4]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 138533487-Methoxy-2,3,4,5-tetrahydro-1h-3-benzazepine

Product 1

HCID 233313912,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrobromide

Conditions

Temperature
100 °C

Procedure

7-Methoxy-2,3,4,5-tetrahydro-1H-3-benzazepine (10 g) (known from M. Kanao et al., Chem. Pharm. Bull. 1982, 30, 180-188) in 48% aqueous hydrobromic acid (350 ml) was allowed to stir at 100° C. for 4 h. The mixture was cooled to 20° C. then evaporated to dryness in vacuo to give the title compound (14.5 g) as a brown solid.

Workup

  1. temperatureThe mixture was cooled to 20° C.
  2. customthen evaporated to dryness in vacuo

Sources & evidence

ORD record
ord-27c501d0fc8f43148348c03bf20cd060
Source dataset
uspto-grants-2008_09
Patent number
US07429579B2

Reaction notes

Loading…