反应详情

To 100 mg 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-hydroxymethyl-1H-pyrazole-3-carboxylic acid in 2 ml DCM and 0.1 ml NEt3, 67 mg 4-(4-Amino-phenyl)-morpholin-3-one and 74 mg BOP-Cl were added at RT and the mixture was stirred for 16 h. The mixture was concentrated under reduced pressure and triturated in a mixture of water/DMF. The precipitate was collected by filtration and washed with water containing 0.5% TFA. The product was obtained as a white solid which was dried under reduced pressure.

1. concentrationThe mixture was concentrated under reduced pressure
2. customtriturated in a mixture of water/DMF
3. filtrationThe precipitate was collected by filtration
4. washwashed with water containing 0.5% TFA
5. customThe product was obtained as a white solid which
6. customwas dried under reduced pressure