3-Amino-1-propanol → HCID 86003215, compound

HRID 332595Notes

Reaction equation

HRID 332595 reaction equation
[OH:1][CH2:2][CH2:3][CH2:4][NH2:5].O([Si:14]([CH:21]([CH3:23])[CH3:22])([CH:18]([CH3:20])[CH3:19])[CH:15]([CH3:17])[CH3:16])S(C(F)(F)F)(=O)=O>ClCCl>[CH:15]([Si:14]([CH:21]([CH3:23])[CH3:22])([CH:18]([CH3:20])[CH3:19])[O:1][CH2:2][CH2:3][CH2:4][NH2:5])([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 90863-Amino-1-propanolHCID 2724529Triisopropylsilyl trifluoromethanesulfonate

Product 1

HCID 86003215HCID 86003215, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-Hydroxylpropylamine (100 μL, 1.31 mmol) was dissolved in dichloromethane (4.4 mL), and triisopropylsilyl triflate (371 μL, 1.38 mmol) was added dropwise at room temperature. After stirring at room temperature for 15 minutes, the mixture was worked up according to a conventional method to give the title compound as a crude product.

Sources & evidence

ORD record
ord-1f1e2e693332409b9da7f25293c22d3f
Source dataset
uspto-grants-2014_11
Patent number
US08877805B2

Reaction notes

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