Hydrochloric Acid → HCID 71257117, compound

HRID 332673Notes

Reaction equation

HRID 332673 reaction equation
C(OC(=O)[NH:7][CH:8]([C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH2:22][C:23]2[CH:24]=[C:25]([C:29]3[CH:34]=[CH:33][C:32]([CH2:35][CH:36]4[O:40][CH2:39][CH2:38][O:37]4)=[CH:31][CH:30]=3)[CH:26]=[CH:27][CH:28]=2)[CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(C)(C)C.[ClH:42]>CO.O1CCOCC1>[ClH:42].[O:37]1[CH2:38][CH2:39][O:40][CH:36]1[CH2:35][C:32]1[CH:31]=[CH:30][C:29]([C:25]2[CH:26]=[CH:27][CH:28]=[C:23]([CH2:22][O:21][C:17]3[CH:16]=[C:15]([CH:8]([C:9]4[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=4)[NH2:7])[CH:20]=[CH:19][CH:18]=3)[CH:24]=2)=[CH:34][CH:33]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 71263276HCID 71263276, compound

Product 1

HCID 71257117HCID 71257117, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl((3-((4′-((1,3-dioxolan-2-yl)methyl)-[1,1′-biphenyl]-3-yl)methoxy)phenyl)(phenyl)methyl)carbamate (1.44 g, 2.6 mmol) in methanol (6.5 mL), was added hydrogen chloride in dioxan (6.5 mL). The reaction mixture was stirred at ambient temperature for 16 hours. The solvent was evaporated to afford a mixture of the title compound and the corresponding dimethyl acetal. The material was used in the next step without further purification.

Workup

  1. customThe solvent was evaporated
  2. customto afford

Sources & evidence

ORD record
ord-6f36525b31c740b8b051a26681b442ee
Source dataset
uspto-grants-2014_11
Patent number
US08877774B2

Reaction notes

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