反应详情

To a stirred suspension of methyl 4-((3-(azido(phenyl)methyl)phenoxy)-methyl)benzoate (1 g, 2.79 mmol) in methanol (25 mL), was added 2M sodium hydroxide (25 mL). The reaction was allowed to stir at room temperature for 3 days. Tetrahydrofuran (10 mL) was added to the reaction mixture, and the mixture was stirred at 50° C. for 4 hours followed by 16 hours at room temperature. The reaction mixture was acidified with 10% hydrochloric acid, extracted with dichloromethane, dried (sodium sulphate), filtered, and concentrated under reduced pressure to give the title compound (1 g, quantitative).

1. stirringthe mixture was stirred at 50° C. for 4 hours
2. waitfollowed by 16 hours at room temperature
3. extractionextracted with dichloromethane
4. dry with materialdried (sodium sulphate)
5. filtrationfiltered
6. concentrationconcentrated under reduced pressure