反应详情

温度

110 °C

The mixture of tert-tutyl ((1S,2R)-2-((6-chloro-5-cyanopyrazin-2-yl)amino)cyclohexyl)carbamate (90 mg, 0.26 mmol), 3,5-di(2H-1,2,3-triazol-2-yl)aniline (88 mg, 0.39 mmol), powder cesium carbonate (340 mg, 1.04 mmol), BINAP (31 mg, 0.05 mmol), Pd(OAc)2 (12 mg, 0.05 mmol) in 15 mL dioxane was degassed with argon stream. It was stirred in argon atmosphere at 110° C. for 16 h. The mixture was cooled, diluted with 100 mL EtOAc, vigorously stirred, and filtered through celite. The filtrate was concentrated and subjected to silica flash column with 0-55% EtOAc in hexane to isolate the coupling product. It was then stirred in 5 mL TFA and 1 mL conc. H2SO4 at 80° C. for 20 m. It was cooled in ice bath, diluted with water, filtered, and subjected to reverse phase preparative HPLC to isolate the title compound (18 mg). MS found for C21H24N120 as (M+H)+ 461.5. UV: λ=259, 311 nm. 1H NMR: (CD3OD) δ 8.52 (2H, d, J=1.6 Hz), 8.43 (1H, t, J=1.6 Hz), 8.01 (4H, s), 7.61 (2H, s), 4.83 (1H, m), 3.76 (1H, m), 1.93-1.55 (8H, m) ppm.

1. customwas degassed with argon stream
2. temperatureThe mixture was cooled
3. additiondiluted with 100 mL EtOAc
4. stirringvigorously stirred
5. filtrationfiltered through celite
6. concentrationThe filtrate was concentrated
7. customto isolate the coupling product
8. customat 80° C.
9. temperatureIt was cooled in ice bath
10. filtrationfiltered