反应详情

2-Chloro-4-nitro-6-methyl-pyridine 1-oxide (6.2 g, 0.033 mol) was dissolved in chloroform (100 ml), phosphorus trichloride was added (22.6 g, 0.165 mol) and the mixture was heated under reflux for 2 days. The mixture was cooled to room temperature, poured into icewater and the mixture was neutralized with solid potassium carbonate. The phases were separated, the aqueous phase was extracted three times with chloroform, the combined organic phases were dried over magnesium sulfate. The solvent was removed under reduced pressure after which 5.326 g of a brown oil was obtained (0.031 mol, 94%) which was used directly in the next step.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 2 days
3. additionpoured into icewater
4. customThe phases were separated
5. extractionthe aqueous phase was extracted three times with chloroform
6. dry with materialthe combined organic phases were dried over magnesium sulfate
7. customThe solvent was removed under reduced pressure after which 5.326 g of a brown oil
8. customwas obtained (0.031 mol, 94%) which