Trifluoroacetic acid → HCID 66819661, compound

HRID 333226Notes

Reaction equation

HRID 333226 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][C:16](=[O:33])[NH:17][C:18]1[CH:31]=[CH:30][C:29]2[NH:28][C:27](=[O:32])[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:20]=2[CH:19]=1)(C)(C)C.[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38]>ClCCl>[F:35][C:36]([F:41])([F:40])[C:37]([OH:39])=[O:38].[NH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][NH:14][CH2:15][C:16]([NH:17][C:18]1[CH:31]=[CH:30][C:29]2[NH:28][C:27](=[O:32])[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[C:20]=2[CH:19]=1)=[O:33]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66819636(6-{[(6-Oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-hexyl)-carbamic acid tert-butyl ester

Product 1

HCID 66819661HCID 66819661, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(6-{[(6-oxo-5,6-dihydro-phenanthridin-2-ylcarbamoyl)-methyl]-amino}-hexyl)-carbamic acid tert-butyl ester was dissolved in dichloromethane (5 mL) and trifluoroacetic acid (1.5 mL) was added. The reaction mixture was stirred at room temperature overnight, evaporated, taken up with diethyl ether, filtered and the collected solid was dried under vacuum to afford 30 mg (65% yield) of the title compound as a light-yellow solid.

Workup

  1. customevaporated
  2. filtrationfiltered
  3. customthe collected solid was dried under vacuum

Sources & evidence

ORD record
ord-3ce85afeef0641a89234fb1c9fc88e2d
Source dataset
uspto-grants-2014_11
Patent number
US08877944B2

Reaction notes

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