Methylamine → 1-(4-fluorophenyl)-N-methylcyclohexanecarboxamide

HRID 333250Notes

Reaction equation

HRID 333250 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([OH:16])=O)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[CH3:17][NH2:18]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:14]([NH:18][CH3:17])=[O:16])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 7361361-(4-Fluorophenyl)cyclohexane-1-carboxylic acid

Product 1

HCID 473985081-(4-fluorophenyl)-N-methylcyclohexanecarboxamideYield 86%

Procedure

The title compound was synthesized from 1-(4-fluorophenyl)cyclohexane-carboxylic acid (222 mg, 1 mmol) and methylamine (1 mL, 1M in THF, 1 eq) according to General Procedure G. The crude product was purified by silica gel column chromatography to give the amide (202.6 mg, 86%) as a white solid.

Workup

  1. customThe crude product was purified by silica gel column chromatography

Sources & evidence

ORD record
ord-34f5ab35e34a48338704b61c733c477f
Source dataset
uspto-grants-2014_11
Patent number
US08877975B2

Reaction notes

Loading…