Trifluoroacetic acid → HCID 66988243, compound

HRID 333430Notes

Reaction equation

HRID 333430 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]1([O:19][CH2:20][CH2:21][CH3:22])[CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1.[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26]>ClCCl>[F:23][C:24]([F:29])([F:28])[C:25]([OH:27])=[O:26].[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][CH:3]1[C:8]1([O:19][CH2:20][CH2:21][CH3:22])[CH2:9][NH:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66987895HCID 66987895, compound

Product 1

HCID 66988243HCID 66988243, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

91 mg (0.29 mmol) of tert-butyl 3-(2-methylcyclohexyl)-3-propoxyazetidine-1-carboxylate are dissolved in 8 mL of dichloromethane. The reaction medium is immersed in an ice bath. 2 mL of trifluoroacetic acid are added. After 1 hour, the solvents are evaporated off. 113 mg in the form of a brown oil are used in the following step without further purification.

Workup

  1. customThe reaction medium is immersed in an ice bath
  2. customthe solvents are evaporated off
  3. custom113 mg in the form of a brown oil are used in the following step without further purification

Sources & evidence

ORD record
ord-4a3e526f68cb4d22856fde12304afa79
Source dataset
uspto-grants-2014_11
Patent number
US08877968B2

Reaction notes

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