Thionyl Chloride → HCID 178466769, compound

HRID 333636Notes

Reaction equation

HRID 333636 reaction equation
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[N:11][C:12](=[C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][C:18]([CH3:27])([CH3:26])[NH:17]2)[C:13]([NH2:15])=O)=[CH:6][CH:5]=1)(=[O:3])[CH3:2].S(Cl)(Cl)=O>CN(C=O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]=[N:11][C:12](=[C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][C:18]([CH3:27])([CH3:26])[NH:17]2)[C:13]#[N:15])=[CH:6][CH:5]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 178466770HCID 178466770, compound

Product 1

HCID 178466769HCID 178466769, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2-(4-acetyl-phenylazo)-2-(3,3-dimethyl-3,4-dihydro-2H-isoquinoline-1-ylidene)-acetamide (Asinex Corp., Russia), thionyl chloride and DMF are mixed and stirred slowly. An excess of thionyl chloride is removed from the mixed solvent by reducing the pressure. The residue containing the reaction product is purified by column chromatography to obtain the title compound.

Workup

  1. customAn excess of thionyl chloride is removed from the mixed solvent
  2. additionThe residue containing the reaction product
  3. customis purified by column chromatography

Sources & evidence

ORD record
ord-185e46c3959f47cdae253a5af0d8ff7b
Source dataset
uspto-grants-2014_11
Patent number
US08883504B2

Reaction notes

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