1,1'-Carbonyldiimidazole → HCID 86603969, compound

HRID 33369Notes

Reaction equation

HRID 33369 reaction equation
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[NH:12][CH2:13][CH2:14][C:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:17])[CH3:16].[C:26](N1C=CN=C1)(N1C=CN=C1)=[O:27]>>[CH3:16][C:15]([NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22])([CH3:17])[CH2:14][CH2:13][N:12]1[C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:11])([F:10])[F:9])=[CH:7][C:2]=2[NH:1][C:26]1=[O:27]

Participants

3

Reactant 2

HCID 682631,1'-CarbonyldiimidazoleHCID 86603970HCID 86603970, compound

Product 1

HCID 86603969HCID 86603969, compound

Procedure

5.00 g (13.8 mmol) tert-butyl [3-(2-amino-4-trifluoromethyl-phenylamino)-1,1-dimethyl-propyl]-carbamate and 6.73 g (41.5 mmol) 1,1′-carbonyldiimidazole are reacted and worked up analogously to method 2c). White solid. Yield: 4.18 g (78%); mass spectroscopy: [M−H]+=386.

Sources & evidence

ORD record
ord-7d4c92c665c74979b77007fc0d9312d3
Source dataset
uspto-grants-2008_09
Patent number
US07429583B2

Reaction notes

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