Hydrogen Bromide → 2-Amino-6-benzothiazolol

HRID 333717Notes

Reaction equation

HRID 333717 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11]C)[CH:8]=[CH:7][C:5]=2[N:6]=1.Br>>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([OH:11])[CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

3

Reactant 2

HCID 260Hydrogen BromideHCID 156302-Amino-6-methoxybenzothiazole

Product 1

HCID 334622-Amino-6-benzothiazolol

Procedure

2-Amino-6-methoxybenzothiazole is reacted with hot aqueous HBr for about 3 hrs and then the clear solution is cooled to ambient temperature overnight. The precipitated solids are collected, dissolved in hot water and the pH is adjusted to between 4.5-5.5. The resultant solids are collected, dried and recrystallized from Isopropanol. Second crop material is collected. The solids are vacuum dried to give Intermediate 1.

Workup

  1. customThe precipitated solids are collected
  2. dissolutiondissolved in hot water
  3. customThe resultant solids are collected
  4. customdried
  5. customrecrystallized from Isopropanol
  6. customSecond crop material is collected
  7. customdried

Sources & evidence

ORD record
ord-42e0bd2f1d2b427caa69b72edb240218
Source dataset
uspto-grants-2014_11
Patent number
US08883783B2

Reaction notes

Loading…