反应详情

4.64 g (25 mmol) 2-bromo-2-methyl-propionyl chloride are added dropwise at 5 to 20° C. to a solution of 5.15 g (20 mmol) 1-(3-amino-5-benzyloxy-2-hydroxy-phenyl)-ethanone in 20 mL pyridine. After the addition has ended the mixture is stirred for 15 minutes, combined with ice water and 100 mL ethyl acetate and acidified with conc. hydrochloric acid. The organic phase is separated off, washed with water and dried with sodium sulphate. After the solvent has been distilled off the residue is crystallised from a diethyl ether/petroleum ether mixture.

1. additionAfter the addition
2. customThe organic phase is separated off
3. washwashed with water
4. dry with materialdried with sodium sulphate
5. distillationAfter the solvent has been distilled off the residue
6. customis crystallised from a diethyl ether/petroleum ether mixture