Potassium Hydroxide → HCID 57421236, compound

HRID 333788Notes

Reaction equation

HRID 333788 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][C:14]=1[CH:15]([CH3:29])[C:16]([OH:28])([C:21]1[CH:26]=[N:25][C:24]([CH3:27])=[CH:23][N:22]=1)[C:17]([F:20])([F:19])[F:18])[O:5][CH2:6][CH2:7][O:8]C(=O)C.[OH-].[K+]>C(O)C.C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([O:5][CH2:6][CH2:7][OH:8])[CH:12]=[CH:13][C:14]=1[CH:15]([CH3:29])[C:16]([C:21]1[CH:26]=[N:25][C:24]([CH3:27])=[CH:23][N:22]=1)([OH:28])[C:17]([F:19])([F:20])[F:18]

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 57421233HCID 57421233, compound

Product 1

HCID 57421236HCID 57421236, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

A solution of acetic acid 2-{3-chloro-4-[3,3,3-trifluoro-2-hydroxy-1-methyl-2-(5-methyl-pyrazin-2-yl)-propyl]-phenoxy}-ethyl ester in ethanol was added to a solution of KOH in ethanol. The reaction mixture was stirred for 3 h at r.t., before it was taken up in ethyl acetate, washed with water and brine, and the solvent was evaporated. Flash chromatography provided the title compound. MS (m/e)=391.0 (MH+).

Workup

  1. washwashed with water and brine
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-eba0bbe9c2004329a403667b2f5ab9da
Source dataset
uspto-grants-2014_11
Patent number
US08883786B2

Reaction notes

Loading…