反应详情

First of all 0.624 g (13.9 mmol) 60% sodium hydride and then, with cooling, 4.6 g (17.8 mmol) 1-iodo-4-methyl-4-nitro-pentane in 10 mL DMF are added to a solution of 2.1 g (12.6 mmol) 5-fluoro-1-methyl-1,3-dihydro-benzimidazol-2-one in DMF. The reaction mixture is stirred overnight at ambient temperature, then poured onto water and extracted with diethyl ether. The organic phases are evaporated down and the residue is recrystallised from isopropylether. Yield: 1.8 g (48%); mass spectroscopy [M+H]+=296.

1. additionpoured onto water
2. extractionextracted with diethyl ether
3. customThe organic phases are evaporated down
4. customthe residue is recrystallised from isopropylether