Benzoyl chloride, 3-chloro- → HCID 71604280, compound

HRID 334086Notes

Reaction equation

HRID 334086 reaction equation
FC(F)(F)C(O)=O.[Cl:8][C:9]1[CH:10]=[C:11]([N:15]2[CH:19]=[N:18][C:17]([C:20]([N:22]3[CH2:27][CH2:26][NH:25][CH2:24][C:23]3([CH3:29])[CH3:28])=[O:21])=[N:16]2)[CH:12]=[CH:13][CH:14]=1.CCN(C(C)C)C(C)C.[Cl:39][C:40]1[CH:41]=[C:42]([CH:46]=[CH:47][CH:48]=1)[C:43](Cl)=[O:44]>CN(C=O)C>[Cl:39][C:40]1[CH:41]=[C:42]([CH:46]=[CH:47][CH:48]=1)[C:43]([N:25]1[CH2:26][CH2:27][N:22]([C:20]([C:17]2[N:18]=[CH:19][N:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([Cl:8])[CH:10]=3)[N:16]=2)=[O:21])[C:23]([CH3:29])([CH3:28])[CH2:24]1)=[O:44]

Participants

5

Reactant 3

HCID 69252Benzoyl chloride, 3-chloro-HCID 81531DiisopropylethylamineHCID 86688261[1-(3-Chloro-phenyl)-1H-[1,2,4]-triazol-3-yl]-(2,2-dimethyl-piperazin-1-yl)methanone trifluoroacetate

Product 1

HCID 71604280HCID 71604280, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 43 mg (0.10 mmol) [1-(3-chloro-phenyl)-1H-[1,2,4]triazol-3-yl]-(2,2-dimethyl-piperazin-1-yl)-methanone trifluoroacetate and 43 μL (0.25 mmol) DIPEA in 1.0 mL DMF was added 13 μL (0.10 mmol) 3-chloro-benzoyl chloride. The reaction mixture was stirred at RT for 30 min and purified by HPLC.

Workup

  1. custompurified by HPLC

Sources & evidence

ORD record
ord-36aa9c3d6be3443eb57b04908ae3aa52
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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