HCID 86688292, compound → HCID 86688309, compound

HRID 334087Notes

Reaction equation

HRID 334087 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[N:11][C:10]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([C:29]5[CH2:30][CH2:31][O:32][CH2:33][CH:34]=5)[N:24]=4)=[O:22])[CH2:17][C:16]3([CH3:36])[CH3:35])=[O:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1>[Pd].CCOC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[CH:12]=[N:11][C:10]([C:13]([N:15]3[CH2:20][CH2:19][N:18]([C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([CH:29]5[CH2:30][CH2:31][O:32][CH2:33][CH2:34]5)[N:24]=4)=[O:22])[CH2:17][C:16]3([CH3:36])[CH3:35])=[O:14])=[N:9]2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 86688292HCID 86688292, compound

Product 1

HCID 86688309HCID 86688309, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 17 mg (34 μmol) [1-(3-chloro-phenyl)-1H-[1,2,4]-triazol-3-yl]-{4-[6-(3,6-dihydro-2H-pyran-4-yl)-pyridine-2-carbonyl]-2,2-dimethyl-piperazin-1-yl}-methanone and 4 mg palladium on carbon in 5.0 mL EtOAc was hydrogenated at RT for 4 days. The catalyst was removed by filtration and the solvent was evaporated in vacuo. The resulting residue was purified by HPLC.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe solvent was evaporated in vacuo
  3. customThe resulting residue was purified by HPLC

Sources & evidence

ORD record
ord-22774aadfe774b36a8c3aa5711632fbb
Source dataset
uspto-grants-2014_11
Patent number
US08883789B2

Reaction notes

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