反应详情

50.4 g (0.223 mol) 9-hydroxy-9-fluorenecarboxylic acid are dissolved in 500 ml of methanol, combined with 5 ml (0.089 mol) conc. sulphuric acid and refluxed for 1 hour. After cooling 100 ml sodium hydrogen carbonate solution (about pH 8) are added, and the methanol is largely distilled off under reduced pressure. The residue remaining is extracted with dichloromethane and water, the organic phase is dried and evaporated to dryness.

1. temperaturerefluxed for 1 hour
2. additionare added
3. distillationthe methanol is largely distilled off under reduced pressure
4. extractionThe residue remaining is extracted with dichloromethane and water
5. customthe organic phase is dried
6. customevaporated to dryness