1-(2-Methoxyphenyl)piperazine → HCID 71602689, compound

HRID 334287Notes

Reaction equation

HRID 334287 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1.[Cl:15][C:16]1[CH:17]=[C:18]([C:22]2[C:23]([CH:28]=O)=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:19]=[CH:20][CH:21]=1.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].C1(C2C=CC=CC=2)C=CC=CC=1CN1CCN(C2C=CC=CC=2)CC1>>[Cl:15][C:16]1[CH:17]=[C:18]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=2[CH2:28][N:12]2[CH2:13][CH2:14][N:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[O:2][CH3:1])[CH2:10][CH2:11]2)[CH:19]=[CH:20][CH:21]=1

Participants

5

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 13925153'-Chloro[1,1'-biphenyl]-2-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 716025231-(Biphenyl-2-ylmethyl)-4-phenylpiperazine

Product 1

HCID 71602689HCID 71602689, compound

Procedure

250 mg of the target compound (0.64 mmol, 40.5%) was obtained using 1-(2-methoxyphenyl)piperazine (603 mg, 3.14 mmol), 3′-chlorobiphenyl-2-carbaldehyde (340 mg, 1.57 mmol) and NaBH(OAc)3 (1.0 g, 4.71 mmol) according to the synthesis method of Compound 1.

Sources & evidence

ORD record
ord-b144ba9174e5407891d369c7681886c2
Source dataset
uspto-grants-2014_11
Patent number
US08883796B2

Reaction notes

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