反应详情

温度

30 °C

To a 3 L volume four-necked flask, magnesium (cutting chip) (51.4 g) and tetrahydrofuran (anhydrous) (250 ml) were added under a nitrogen atmosphere. After the temperature of the mixture was raised to about 30° C., dibromoethane (17.3 g) was added dropwise. The resulting mixture was stirred for 30 minutes. To the mixture, 1,3,5-triethylbromobenzene (10-b) (443.5 g) dissolved in tetrahydrofuran (250 ml) was added dropwise over 2 hours. The mixture was stirred at 50° C. for 1 hour, and cooled to room temperature to give a solution of 1,3,5-triethylphenylmagnesium bromide in tetrahydrofuran.

1. additionwas added dropwise over 2 hours
2. stirringThe mixture was stirred at 50° C. for 1 hour
3. temperaturecooled to room temperature